Dosimetric Double Network Hydrogel Based on Poly(vinyl-alcohol)/Phenylalanine-Derivatives with Enhanced Mechanical Properties

An innovative double network hydrogel based on poly(vinyl-alcohol) (PVA) cross-linked with glutaraldehyde (GTA) was obtained by the addition of self-assembling phenylalanine (Phe) derivatives aim to achieve improved mechanical-elastic properties exploitable produce 3D dosimeters. The ability in fibrous structures Phe (FmocPhe-OH, A; FmocPhe-Phe-OMe, P) even within PVA gel proved AFM and SEM imaging. proposed matrices containing A P were completely characterized from physical-chemical point view order deeply understand how two molecules influenced properties. Mechanical tests that higher stiffness, toughness, stretchability hydrogels. In particular, these appear peptide matrix could be appropriately tailored regulating concentration added molecule. Preliminary dosimetric studies also performed infusing studied hydrogels Fricke solution. type has been demonstrated suitable for applications avoiding any effect dose response hydrogel. This work presents an unconventional material is able provide clinicians medical physicists effective reliable measurements development anthropomorphic phantoms mimic mechanical radiological human tissues.